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Specified compounds present in grapefruit are identified to inhibit CYP450 3A4 and will boost the bioavailability of swallowed fentanyl (reportedly around 75% of the dose) and Grownup:Patches provide fentanyl in doses that range between: 12-100 mcg/hr. Doses really should be individually titrated dependant on past use of opioids. Opioid-naive pe